Hierarchical Modularity in ERα Transcriptional Network Is Associated with Distinct Functions and Implicates Clinical Outcomes
نویسندگان
چکیده
Recent genome-wide profiling reveals highly complex regulation networks among ERα and its targets. We integrated estrogen (E2)-stimulated time-series ERα ChIP-seq and gene expression data to identify the ERα-centered transcription factor (TF) hubs and their target genes, and inferred the time-variant hierarchical network structures using a Bayesian multivariate modeling approach. With its recurrent motif patterns, we determined three embedded regulatory modules from the ERα core transcriptional network. The GO analyses revealed the distinct biological function associated with each of three embedded modules. The survival analysis showed the genes in each module were able to render a significant survival correlation in breast cancer patient cohorts. In summary, our Bayesian statistical modeling and modularity analysis not only reveals the dynamic properties of the ERα-centered regulatory network and associated distinct biological functions, but also provides a reliable and effective genomic analytical approach for the analysis of dynamic regulatory network for any given TF.
منابع مشابه
Mining Overlapping Communities in Real-world Networks Based on Extended Modularity Gain
Detecting communities plays a vital role in studying group level patterns of a social network and it can be helpful in developing several recommendation systems such as movie recommendation, book recommendation, friend recommendation and so on. Most of the community detection algorithms can detect disjoint communities only, but in the real time scenario, a node can be a member of more than one ...
متن کاملHierarchical Facility Location and Hub Network Problems: A literature review
In this paper, a complete review of published researches about hierarchical facility location and hub network problems is presented. Hierarchical network is a system where facilities with different service levels interact in a top-down way or vice versa. In Hierarchical systems, service levels are composed of different facilities. Published papers from (1970) to (2015) have been studied and a c...
متن کاملModels of EFL Learners’ Vocabulary Development: Spreading Activation vs. Hierarchical Network Model
Semantic network approaches view organization or representation of internal lexicon in the form of either spreading or hierarchical system identified, respectively, as Spreading Activation Model (SAM) and Hi- erarchical Network Model (HNM). However, the validity of either model is amongst the intact issues in the literature which can be studied through basing the instruction compatible wi...
متن کاملOptimizing a Hierarchical Hub Covering Problem with Mandatory Dispersion of Central Hubs
The hierarchical hub location problem is encountered three-level network that is applied in production-distribution system, education system, emergency medical services, telecommunication network, etc. This paper addresses the hierarchical hub covering problem with single assignment accounting for mandatory dispersion of central hubs restriction as a special case. This formulation with incorpor...
متن کاملHierarchical organization of modularity in metabolic networks.
Spatially or chemically isolated functional modules composed of several cellular components and carrying discrete functions are considered fundamental building blocks of cellular organization, but their presence in highly integrated biochemical networks lacks quantitative support. Here, we show that the metabolic networks of 43 distinct organisms are organized into many small, highly connected ...
متن کامل